There is some risk of recurrence after SCAD, and most patients will be followed by a cardiologist long-term. Up to 19% of people who have had an arterial dissection will have another one, making it especially important for SCAD patients to seek treatment if they experience signs of a heart attack immediately.

In women who have had a pregnancy-related SCAD, there is concern that another pregnancy will also be complicated by SCAD. In one small study, one in seven women who had pregnancy-related SCAD had recurrent issues during subsequent pregnancies. Some clinicians recommend avoiding future pregnancies, while other suggest careful consultation with a specialist during subsequent pregnancies.